Aqueous extract of the comfrey root effect on cell proliferation in concentrations higher than 40 µg/ml was significantly stimulatory for L929 but inhibitory for MDCK cells. Pure allantoin showed mild inhibitory effect on proliferation of both cell lines at concentrations 40 and 100 µg/ml, but more pronounced on MDCK cells. Anti-irritant potential was determined by measuring electrical capacitance, erythema index (EI) and transepidermal water loss of artificially irritated skin of young healthy volunteers, 3 and 7 days after application of creams and gels with PA or AECR. Cell viability and proliferation of epithelial (MDCK) and fibroblastic (L929) cell line were studied by using MTT test. Dietary Supplements: What You Need to Know.This study investigates the biological activity of pure allantoin (PA) and aqueous extract of the comfrey (Symphytum officinale L.) root (AECR) standardized to the allantoin content. Comfrey root: from tradition to modern clinical trials. Herbal medicine for low back pain: A Cochrane review. Gagnier JJ, Oltean H, van Tulder MW, Berman BM, Bombardier C, Robbins CB. Acupuncture for Chronic Pain: Update of an Individual Patient Data Meta-Analysis. Vickers AJ, Vertosick EA, Lewith G, et al. Complementary Health Approaches for Chronic Pain: What the Science Says. National Center for Complementary and Integrative Health. Liver injury from herbal and dietary supplements. Navarro VJ, Khan I, Björnsson E, Seeff LB, Serrano J, Hoofnagle JH. Medline Plus, National Library of Medicine. Tolerability and effectiveness of an antitrauma cream with comfrey herb extract in pediatric use with application on intact and on broken skin. Kucera A, Barna M, Holcova S, Horacek O, Hladiková M, Ottillinger B. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Library of Medicine, National Institutes of Health. Pyrrolizidine Alkaloids: Chemistry, Pharmacology, Toxicology and Food Safety. Moreira R, Pereira DM, Valentão P, Andrade PB. A critical scoping review of external uses of comfrey (Symphytum spp.). Transcriptomic profiling for safety and toxicity evaluation of nutraceuticals. In: Toxicological Survey of African Medicinal Plants. Subchronic and chronic toxicities of african medicinal plants. Treatment with 4Jointz reduces knee pain over 12 weeks of treatment in patients with clinical knee osteoarthritis: a randomised controlled trial. Laslett LL, Quinn SJ, Darian-Smith E, et al. Effect of a blend of comfrey root extract (Symphytum officinale L.) and tannic acid creams in the treatment of osteoarthritis of the knee: randomized, placebo-controlled, double-blind, multiclinical trials. Topical herbal therapies for treating osteoarthritis. Efficacy and safety of comfrey root extract ointment in the treatment of acute upper or lower back pain: results of a double-blind, randomised, placebo-controlled, multicentre trial. Giannetti BM, Staiger C, Bulitta M, Predel HG. Comfrey.ĭrugs and Lactation Database, National Library of Medicine. A systematic review and quality assessment of case reports of adverse events for borage (Borago officinalis), coltsfoot (Tussilago farfara) and comfrey (Symphytum officinale). doi:10.3390/molecules24122272Īvila C, Breakspear I, Hawrelak J, Salmond S, Evans S. Symphytum species: A comprehensive review on chemical composition, food applications and phytopharmacology. Salehi B, Sharopov F, Boyunegmez Tumer T, et al.
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